Molecular Mechanisms and Biological Functions of siRNA
网页2017年3月30日 · One of the most important advances in biology has been the discovery that siRNA (small interfering RNA) is able to regulate the expression of genes, by a phenomenon known as RNAi (RNA interference).
What is SiRNA? - News-Medical.net
网页2021年5月13日 · siRNA is a double-stranded RNA molecule that is non-coding. It is also known as silencing RNA and short interfering RNA. It is similar to microRNA (miRNA) and the structure is short and...
siRNA: Mechanism of action, challenges, and therapeutic approaches
网页2021年8月15日 · Owing to specific and compelling gene silencing, RNA interference (RNAi) is expected to become an essential approach in treating a variety of infectious, hemato-oncological, cardiovascular, and neurodegenerative conditions. The mechanism of action of small interfering RNA (siRNA) is based on post-tr ….
Therapeutic siRNA: state of the art | Signal Transduction and …
网页2020年6月19日 · All clinically explored and commercialized siRNA delivery platforms, including the GalNAc (N-acetylgalactosamine)–siRNA conjugate, and their fundamental design principles are thoroughly...
A Comprehensive Review of Small Interfering RNAs (siRNAs): …
网页2023年12月13日 · Small interfering RNA (siRNA) delivery by nanocarriers has been identified as a promising strategy in the study and treatment of cancer. Short nucleotide sequences are synthesized exogenously to create siRNA, which triggers RNA interference (RNAi) in cells and silences target gene expression in a sequence-specific way.
siRNA: Mechanism of action, challenges, and therapeutic …
网页2021年8月15日 · siRNA is a negatively charged macromolecule that is susceptible to degradation by serum endonucleases and suffers poor permeability of cell membrane. Therefore, different types of delivery systems have been developed to protect siRNA from degradation and enhance cellular uptake.
Origins and Mechanisms of miRNAs and siRNAs - PMC - National …
网页2009年2月2日 · Two primary categories of these small RNAs— short interfering RNAs (siRNAs) and microRNAs (miRNAs)—act in both somatic and germline line-ages in a broad range of eukaryotic species to regulate endogenous genes and to defend the genome from invasive nucleic acids.
Small interfering RNA: Discovery, pharmacology and clinical
网页2022年10月17日 · Post-transcriptional gene silencing targets and degrades mRNA transcripts, silencing the expression of specific genes. RNA interference technology, using synthetic structurally well-defined short double-stranded RNA (small interfering RNA [siRNA]), has advanced rapidly in recent years.
Small silencing RNAs: an expanding universe - Nature
网页The defining features of small silencing RNAs are their short length (∼ 20–30 nucleotides), and their association with members of the Argonaute family of proteins, which they guide to their...
Small Interfering RNA - an overview | ScienceDirect Topics
网页Small interfering RNA (siRNA), also known as short interfering RNA or silencing RNA, is a kind of non-coding double-stranded RNA containing 21-22 nucleotide base pairs that interfere with the expression of particular genes and mRNA translation by targeting a particular type of gene or mRNA.
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